Turing on Morphogenesis
Shortly before his death Turing did research on Biology, specifically on the formation of patterns. He proposed that under certain conditions diffusion can destabilize a chemical system and cause spatial patterns.
His original paper on the subject can be found at the Turing Archive [turingarchive.org].
More information can be found if you search for “Gierer and Meinhardt” on pattern formation. Here is an interesting introduction to the topic written by P.T. Saunders:
Collected Works of A.M. Turing
Morphogenesis
P.T. Saunders, Editor
Introduction
Turing’s work in biology illustrated just as clearly as his other work his ability to identify a fundamental problem and to approach it in a highly original way, drawing remarkably little from what others had done. He chose to work on the problem of form at a time when the majority of biologists were primarily interested in other questions. There are very few references in these papers, and most of them are for confirmation of details rather than for ideas which he was following up. In biology, as in almost everything else he did within science — or out of it — Turing was not content to accept a framework set up by others.
Even the fact that the mathematics in these papers is different from what he used in his other work is significant. For while it is not uncommon for a newcomer to make an important contribution to a subject, this is usually because he brings to it techniques and ideas which he has been using in his previous field but which are not known in the new one. Now much of Turing’s career up to this point had been concerned with computers, from the hypothetical Turing machine to the real life Colossus, and this might have been expected to have led him to see the development of an organism from egg to adult as being programmed in the genes and to set out to study the structure of the programs. This would also have been in the spirit of the times, because the combining of Darwinian natural selection and Mendelian genetics into the synthetic theory of evolution had only been completed about ten years earlier, and it was in the very next year that Crick and Watson discovered the structure of DNA. Alternatively, Turing’s experience in computing might have suggested to him something like what are now called cellular automata, models in which the fate of a cell is determined by the states of its neighbours through some simple algorithm, in a way that is very reminiscent of the Turing machine.
For Turing, however, the fundamental problem of biology had always been to account for pattern and form, and the dramatic progress that was being made at that time in genetics did not alter his view. And because he believed that the solution was to be found in physics and chemistry it was to these subjects and the sort of mathematics that could be applied to them that he turned. In my view, he was right, but even someone who disagrees must be impressed by the way in which he went directly to what he saw as the most important problem and set out to attack it with the tools that he judged appropriate to the task, rather than those which were easiest to hand or which others were already using. What is more, he understood the full significance of the problem in a way that many biologists did not and still do not. We can see this in the joint manuscript with Wardlaw which is included in this volume, but it is clear just from the comment he made to Robin Gandy (Hodges 1983, p. 431) that his new ideas were “intended to defeat the argument from design”.
This single remark sums up one of the most crucial issues in contemporary biology. The argument from design was originally put forward as a scientific proof of the existence of God. The best known statement of it is William Paley’s (1802) famous metaphor of a watchmaker. If we see a stone on some waste ground we do not wonder about it. If, on the other hand, we were to find a watch, with all its many parts combining so beautifully to achieve its purpose of keeping accurate time, we would be bound to infer that it had been designed and constructed by an intelligent being. Similarly, so the argument runs, when we look at an organism, and above all at a human being, how can we not believe that there must be an intelligent Creator?
Turing was not, of course, trying to refute Paley; that had been done almost a century earlier by Charles Darwin. But the argument from design had survived, and was, and indeed remains, still a potent force in biology. For the essence of Darwin’s theory is that organisms are created by natural selection out of random variations. Almost any small variation can occur; whether it persists and so features in evolution depends on whether it is selected. Consequently we explain how a certain feature has evolved by saying what advantage it gives to the organism, i.e. what purpose it serves, just as if we were explaining why the Creator has designed the organism in that way. Natural selection thus takes over the role of the Creator, and becomes “The Blind Watchmaker” (Dawkins 1986).
Not all biologists, however, have accepted this view. One of the strongest dissenters was D’Arcy Thompson (1917), who insisted that biological form is to be explained chiefly in the same way as inorganic form, i.e., as the result of physical and chemical processes. The primary task of the biologist is to discover the set of forms that are likely to appear. Only then is it worth asking which of them will be selected. Turing, who had been very much influenced by D’Arcy Thompson, set out to put the program into practice. Instead of asking why a certain arrangement of leaves is especially advantageous to a plant, he tried to show that it was a natural consequence of the process by which the leaves are produced. He did not in fact achieve his immediate aim, and indeed more than thirty-five years later the problem of phyllotaxis has still not been solved. On the other hand, the reaction-diffusion model has been applied to many other problems of pattern and form and Turing structures (as they are now called) have been observed experimentally (Castets at al. 1990), so Turing’s idea had been vindicated.